• Kai Kretzschmar, Ph.D.

    The adult stem cell niche in epithelial tissue homeostasis and cancer

    Junior Group Leader at MSNZ Würzburg (Germany)

  • ACADEMIC POSITIONS & EDUCATION

    MSNZ, University Hospital Würzburg (Germany)

    Junior Group Leader, Since January 2020

    Adult stem cells take cues from their microenvironment (termed the ‘niche’) to control smooth transitions between proliferation and differentiation. Such signals are critical to maintain tissue homoeostasis and regenerate the tissue in response to injury. In diseases such as cancer, aberrant (stem) cells can acquire the ability to remodel their microenvironment for the progression of disease. My research explores the bidirectional signalling between adult stem cells and their niche in epithelial tissue homoeostasis and cancer with the oral mucosa as model system. To address these aims, my laboratory uses genetic lineage tracing, single-cell transcriptomics and organoid technology.

    Hubrecht Institute (Utrecht, The Netherlands)

    Postdoctoral Fellow, June 2014 - DecemBer 2019

    I established tools to model the tumour microenvironment in colorectal cancer in vitro using epithelial organoid cultures in the laboratory of Professor Hans C. Clevers. I further studied epidermal stem cells and the regenerative capacity of the adult heart. I was supported by a VENI grant from the Netherlands Organisation of Scientific Research/NWO and long-term fellows of the Human Frontier Science Program/HFSP and the European Molecular Biology Organisation (EMBO).

     

    Activities & Outreach: Hubrecht Institute Postdoc Committee & Career Development Committee

    University of Cambridge (UK)

    Doctor of Philosophy (Ph.D.) in Genetics, May 2014

    I studied epidermal stem cells and the interaction with their mesenchymal niche during homeostasis of adult skin under supervision of Professor Fiona M. Watt at her laboratories at the Cambridge Stem Cell Institute and KCL's Centre for Stem Cells & Regenerative Medicine.

     

    Activities & Outreach: Cambridge Science Festival, Wolfson Research Day, Open Academy Davos

    Goethe University Frankfurt am Main (Germany)

    Degree (Diplom) in Biology, November 2009

    I did my final research project (Diplomarbeit) in Cell and Developmental Biology investigating gap junctional communication in skin.

     

    Activities & Outreach: Students' Parliament, Biology Students’ Council, Open Academy Davos

  • AWARDS, GRANTS & FELLOWSHIPS

    September 2018

    Young Investigator Award of the Fondation Leducq – Transatlantic Network of Excellence on

    Arrhythmogenic Cardiomyopathy

    June 2018

    International Society for Stem Cell Research (ISSCR) travel award

    September 2017

    Cardiovascular Research Netherlands (CVON)-HUSTCARE young talent program research grant

    June 2016-May 2018

    VENI grant from the Netherlands Organisation for Scientific Research (NWO)

    since June 2015

    Human Frontier Science Program (HFSP) long-term fellowship (non-stipendiary fellow: June 2016-May 2018)

    April 2015-December 2016

    European Molecular Biology Organization (EMBO) long-term fellowship (non-stipendiary fellow: June 2015-December 2016)

    March 2015

    Nikon Young Scientist of the German Society for Cell Biology (DGZ)

    June/July 2014

    Else Kröner Fresensius Foundation (EKFS) young scientist fellowship for the 64th Lindau Nobel Laureate Meeting

    June 2013

    British Society for Cell Biology (BSCB) travel award

    June 2013

    Wolfson College Cambridge travel award

    June 2012

    International Society for Stem Cell Research (ISSCR) travel award

    February 2012

    American Association for the Advancement of Science (AAAS)/Science Program for Excellence in Science award

    January 2010-December 2013

    Medical Research Council (MRC) UK Four-Year Ph.D. scholarship

    September 2007-August 2008

    Erasmus scholarship for exchange studies abroad

    March 2005-December 2006

    German National Academic Foundation (Studienstiftung des deutschen Volkes) scholarship for undergraduate studies

  • SELECTED PUBLICATIONS

    Please check PubMed for a complete and updated list of publications.

    Organoids in immunological research.

    NatURE RevIEWS Immunology. 2020 May 20(5):279-293. doi: 10.1038/s41577-019-0248-y.

    Bar-Ephraim YE*, Kretzschmar K* & Clevers H. (* = equal contribution)

    Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.

    Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 JUL; 116(29):14630-14638. doi: 10.1073/pnas.1715272116.

    Boonekamp KE, Kretzschmar K, Wiener DJ, Asra P, Derakhshan S, Puschhof J, López-Iglesias C, Peters PJ, Basak O & Clevers H.

    Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.​

    Cell. 2019 Feb;176(5):1158-1173.e16. doi: 10.1016/j.cell.2018.12.029.

    Gehart H, van Es JH, Hamer K, Beumer J, Kretzschmar K, Dekkers JF, Rios A & Clevers H.

    Profiling proliferative cells and their progeny in damaged murine hearts.

    Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2018. DOI: 10.1073/pnas.1805829115.

    Kretzschmar K*, Post P*, Bannier-Hélaouët M., Mattiotti A, Drost J, Basak O, Li VSW, van den Born M, Gunst QD, Versteeg D, Kooijman L, van der Elst S, van Es JH, van Rooij E, van den Hoff MJB and Clevers H.

    (* denotes equal contribution)

    Wnt/β-catenin signaling in adult mammalian epithelial stem cells.

    Developmental Biology. 2017. doi: 10.1016/j.ydbio.2017.05.015.

    Kretzschmar K & Clevers H.

    Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties

    Nature Cell Biology. 2017 Jun;19(6):603-613. doi: 10.1038/ncb3532.

    Donati D, Rognoni E, Hiratsuka T, Liakath-Ali K, Hoste E, Kar G, Kayikci M, Russell R, Kretzschmar K, Mulder KW, Teichmann SA & Watt, FM.

    Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.

    Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2016 Oct. doi: 10.1073/pnas.1614057113.

    Tetteh PW, Kretzschmar K, Begthel H, van den Born M, Korving J, Morsink F, Farin HF, van Es JH, Offerhaus GJA & Clevers H.

    Organoids: modeling development and the stem cell niche in a dish.

    Developmental Cell. 2016 Sep 26;38(6):590-600. doi: 10.1016/j.devcel.2016.08.014

    Kretzschmar K & Clevers H.

    Compartmentalized epidermal activation of β-catenin differentially affects lineage reprogramming and underlies tumor heterogeneity.

    Cell Reports. 2016 Jan 12;14(2):169-181. doi: 10.1016/j.celrep.2015.12.041

    Kretzschmar K, Weber C, Driskell RR, Calonje, E & Watt FM.

    The androgen receptor antagonizes Wnt/β-catenin signaling in epidermal stem cells.

    Journal of Investigative Dermatology. 2015 Nov;135(11):2753-63. doi: 10.1038/jid.2015.242.

    Kretzschmar K, Cottle DL, Schweiger PJ & Watt FM.

    BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions.

    Stem Cell Reports. 2014 Oct 14;3(4):620-33. doi: 10.1016/j.stemcr.2014.08.007.

    Kretzschmar K, Cottle DL, Donati G, Chiang MF, Quist SR, Gollnick HP, Natsuga K, Lin KI & Watt FM.

    Markers of epidermal stem cell subpopulations in adult mammalian skin.

    Cold Spring Harbor Perspectives in Medicine. 2014 Jul 3;4(10). pii: a013631. doi: 10.1101/cshperspect.a013631. Review.

    Kretzschmar K & Watt FM.

    Distinct fibroblast lineages determine dermal architecture in skin development and repair.

    Nature. 2013 Dec 12;504(7479):277-81. doi: 10.1038/nature12783.

    Driskell RR, Lichtenberger BM*, Hoste E*, Kretzschmar K*, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC & Watt FM. (* denotes equal contribution)

    Lineage tracing.

    Cell. 2012 Jan 20;148(1-2):33-45. doi: 10.1016/j.cell.2012.01.002.

    Kretzschmar K & Watt FM.

    Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin.

    Development. 2011 Dec; 138(23):5189-99. doi: 10.1242/dev.064592.

    Collins CA, Kretzschmar K & Watt FM.

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